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256 Collectively, the Notch pathway undergoes dynamic rewiring in response to therapeutic pressure, reinforcing its role in resistance biology and validating its potential as a target for rational combinatorial interventions

This leads to a state of sympathetic overdrive, where the body is stuck in a perpetual "fight or flight" response, driving up the heart rate and exhausting the cardiovascular system

Obesity and overweight, with or without metabolic dysregulation, pose vexing problems for many patients with mood, anxiety, or psychotic disorders