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JAMA 331 , 16721673 (2024)
Animal studies have revealed embryofetal toxicity at supratherapeutic doses
6 / 11 Taking high doses of corticosteroids for a long time can cause serious side effects like brittle bones that break easily (osteoporosis), slow growth in kids, and a life-threatening condition called adrenal insufficiency, where the body cannot respond to stress such as surgery or illnesses
These effects should be interpreted as context-supportive rather than causative, reinforcing the role of postbiotics as adjunctive modulators within comprehensive body-compositionfocused weight-loss strategies ( Importantly, there are currently no direct human interventional studies demonstrating that postbiotic supplementation preserves skeletal muscle mass during GLP-1based obesity therapy
