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These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying

Washington, DC: The National Academies Press

Symptoms may have other causes and may require blood tests, GP assessment or specialist care

Consumers and practitioners may misinterpret GRAS approval as evidence of efficacy, when in fact the obesity trialthe only controlled efficacy studywas negative

B12 is involved in the production of neurotransmitters that influence alertness and energy