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lean muscle mass loss may also be of greater clinical significance People with cardiovascular disease or arrhythmias : The observed increase in resting heart rate with GLP-1 and glucagon receptor agonism warrants careful monitoring in those with established heart disease or rhythm disorders People with pre-existing diabetic retinopathy : Rapid improvement in HbA1c may be associated with early worsening of retinopathy

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Short-term treatment with a novel HIF-prolyl hydroxylase inhibitor (GSK1278863) failed to improve measures of performance in subjects with claudication-limited peripheral artery disease

When beneficial gut bacteria ferment these fibers, they produce short-chain fatty acids (SCFAs), particularly butyrate