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Injectable delivery produces measurable plasma levels and allows the peptide to reach tissues that topical application cannot including deeper wound beds, joint spaces in preclinical models, and scalp follicles below the penetration limit of topical creams

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Furthermore, 6-shogaol at 0.1, 1, 10, 50, and 100 mM markedly suppressed histamine release activated by secondary metabolite 48/80 in rat peritoneal mast cells

PMID: 10470368 DOI: 10.1016/s0065-2571(98)00029-6

These substances undergo a series of well-coordinated processes that transform lipophilic substances into more hydrophilic forms, facilitating their elimination from the body