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[29, 30, 31] Risk factors: Diabetes (especially in combination with SGLT2 inhibitors use) Reduced oral intake and severe GI symptoms Dehydration Presentation: Nausea, vomiting, abdominal pain Anion gap metabolic acidosis Elevated ketones Normal or mildly elevated glucose Key point: EDKA has not been observed in non-diabetic patients in large cohort data
The upregulation of ATP citrate lyase (ACLY) increases the expression of the resistant proteins such as ABCB1/ABCG2, making breast cancer cells resistant to docetaxel, thereby suggesting ACLY as a potential predictive biomarker of tumor recurrence in breast cancer [138]
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However, individual responses range widely, and some people lose similar amounts at lower doses
Some people experience localized histamine release that causes itching and redness
