GLP-1 medications: Increase insulin secretion Decrease glucagon release Slow gastric emptying Reduce appetite and hunger signaling Act on receptors in the central nervous system GLP-1 receptor activity in the brain, pancreas, liver, stomach, and adipose tissue, reinforce that these medications affect more than weight alone
Most patients tolerate mild-to-moderate reflux with dietary modification and antacid use for 3-7 days before symptoms improve naturally
The obesity drug pipeline is about to get crowded, and that is good news for patients
BMJ 366:l4898 Sterne JA et al (2016) ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions
Oral Protocol Essentials Standard dose: 5001,000 mcg, 12 daily Empty stomach for systemic effects: 3060 minutes before meals or 2 hours after With food for gut-coating effects: take alongside meals Storage: capsules should be refrigerated