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Important safety information includes a boxed warning for thyroid C-cell tumors (contraindicated in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings for pancreatitis, gallbladder disease, acute kidney injury, and hypoglycemia risk when used with insulin or sulfonylureas

Nature 592 , 450456 (2021)

[6] Use on inflamed, infected, or wounded scalp areas may increase irritation risk and is typically deferred until integument integrity is restored

Moreover, MitoTracker Red staining intensity in HepG2 cells was significantly lower in PA-treated cells than control cells

Additionally, alcohol can interfere with B12 storage in the liver