Thus, more efforts are needed to increase folate production levels through metabolic engineering 1,631,632,634,635
Systemic allergic symptoms require more urgent attention and include: Cutaneous manifestations : widespread urticaria (raised, itchy welts), generalised pruritus, flushing, or angioedema affecting the face, lips, tongue, or throat Respiratory symptoms : shortness of breath, wheezing, throat tightness, or stridor (high-pitched breathing sound) Gastrointestinal symptoms : nausea, vomiting, abdominal cramping, or diarrhoea (though these can also be common non-allergic side effects of GLP-1 agonists) Cardiovascular symptoms : dizziness, light-headedness, rapid or weak pulse, or feeling faint Anaphylaxis represents the most severe form of allergic reaction and is characterised by the rapid onset of symptoms affecting multiple organ systems

In addition, any biological material that were collected from DRC-based individuals remains bio banked at the INRB in Kinshasa and managed under the discretion of that local institute, to insure research related to konzo is held at the highest standard when foreign counterparts are involved
The CoQ provides antioxidant protection to cell membranes and plasma lipoproteins
Still, the MHRA makes these determinations on a case-by-case basis when complaints are received or manufacturers seek advice