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(1) S L Teichman, A Neale, B Lawrence, C Gagnon, et al (2005)

In the GLP-1 sector, specific technical transfer challenges include: Peptide Chemistry Complexity: The multi-step SPPS processes have many critical points: resin type, activation reagents, deprotection kinetics

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Significant barriers still exist despite established safety profiles, such as high costs that restrict access worldwide, a lack of predictive biomarkers for treatment response, a lack of knowledge about the mechanistics of gut microbiota interactions, and an incomplete understanding of long-term safety, particularly with regard to thyroid and pancreatic effects

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