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In coordination with histamine, heparin and other inflammatory cells, the body reacts with symptoms ranging from skin reactions including hives, folliculitis, redness and psoriasis, to respiratory symptoms including asthma, shortness of breath, cough and mucous production, to Irritable Bowel with constipation or diarrhea and bloating
One notable example is research by Khorram et al
The good news: most side effects diminish or disappear within the first week as tolerance develops
Cost and insurance coverage
Another prominent genetic variant associated with serum urate levels is rs1263026 at GCKR
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