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This balance between IGF-1 and growth hormone is critical to human growth and development
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Two possible roles have been suggested: biotransformation of electrophilic compounds, protecting the DNA content, where the GST catalyzes the conjugation of glutathione to the xenobiotic compound in a detoxification-related mechanism, and a possible role in modulating gene expression
& Genc, K
For example, autocrine/paracrine actions may also be important in conditions such as diabetic retinopathy because GH expression occurs in ocular tissues
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