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The American Journal of Clinical Nutrition 35, 1417-1424

The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9

Initial testing: Do CBC and B12 tests before starting treatment and again after the first dose

Evidence-based guidance for genuine needs When supplements are genuinely necessary, follow evidence-based dosing and timing recommendations

Stratify surgical bleeding and aspiration risk to guide hold time