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Comparison to Other GLP-1 Medications Retatrutide's BP reduction exceeds other obesity medications: Semaglutide (Wegovy): -6.2 mmHg systolic Tirzepatide (Zepbound): -8.0 mmHg systolic (15mg, SURMOUNT-1) Retatrutide: -14.0 mmHg systolic The addition of glucagon receptor agonism likely contributes
During dose escalation: Fatigue may persist or temporarily worsen with each dose increase, in line with observations from the Phase 2 trial protocol
Dehydration leading to kidney problems
Clinical trials included adults aged 18 and older
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