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While also underpowered to detect clinical events, there was a signal noted towards reduction of the first HF event (HR 0.40
As the American Urological Association guidelines on ED note, first-line therapy remains PDE5 inhibitors (sildenafil, tadalafil, vardenafil, avanafil), with bremelanotide not yet included in any major guideline algorithm for male sexual dysfunction [7]
Once in circulation, GLP-1 is rapidly degraded by DPP-4, which cleaves the active hormone to form GLP-1(9-36) with significantly reduced insulinotropic activity
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