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Furthermore, IGF-1 may regulate A plaque concentrations, as lower circulating IGF-1 have been associated with A plaque accumulation in the rodent brain (Carro et al., 2002)

153,154 Under conditions of insufficient glycolysis caused by glucose deprivation, 2-deoxyglucose treatment or Akt signaling inhibition, glutamine-addicted cells are more sensitive to GDH1 deficiency

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The kinetics of sinusoidal efflux of GSH has been well studied in the perfused rat liver