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Contact your provider if you observe: Resting heart rate consistently above 100 BPM An increase of 10 bpm or more from your baseline that persists New or worsening: Palpitations Chest discomfort Dizziness Shortness of breath What To Tell Your Prescriber Before Beginning Treatment People with the following conditions should notify their prescriber before starting semaglutide: Tell your clinician about any history of: Heart disease Heart failure Arrhythmia Fainting Thyroid cancer Pancreatitis Digestive motility problems Kidney disease Eye disease All current medications and supplements Also mention lifestyle factors like caffeine and stimulant use

Since then, the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) cardiovascular outcomes trial has shown that semaglutide 2.4 mg once weekly was associated with a significant 20% relative risk reduction in major cardiovascular adverse events compared with placebo [38]

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The muscle growth protocols page has additional guidance on timing nutrition around exercise

More research is underway, including clinical trials looking at semaglutides role in preventing Alzheimers disease