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Meanwhile, GLP-1 receptor activation links with neurotrophic effects, including neurogenesis and neuroprotective effects, including reduced necrotic and apoptotic signaling, cell death, and dysfunctions

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[1] [2] This trial enrolled adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity the primary cohort was largely without type 2 diabetes and assessed multiple doses of retatrutide against placebo over 24 weeks, with an extension to 48 weeks

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