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Semaglutide was originally developed for type 2 diabetes, where it produces HbA1c reductions of 1.52.0 percentage points

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According to the Summary of Product Characteristics (SmPC), no dose adjustment is required based on renal or hepatic impairment, though clinical experience is limited in patients with severe renal impairment or end-stage kidney disease

NICE Clinical Guideline 184 on dyspepsia and gastro-oesophageal reflux disease provides principles for managing these symptoms