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Cell Immunol 149:433443
The deiodinases DIO1 and DIO2 can activate T4 by transforming it into T3 by removal of the 5-iodine, while DIO1 and DIO3 can prevent T4 from being activated by converting it to the inactive reverse T3 ( Reference Darras and Van Herck 68 ) (Fig
This does not mean higher doses are beneficial, only that accidental overdose within reasonable ranges carries minimal acute risk
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