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55 Epigenetic reprogramming, including DNA methylation and histone modifications, as well as noncoding RNAs (e.g., miRNAs, lncRNAs), further modulates transcriptional landscapes to maintain stemness and reshape the TME, thereby reinforcing resistance to chemotherapy
Moreover, prominin-2, a member of the prominin family of pentaspan membrane glycoproteins, can mediate the release of ferritin into the extracellular space by exosomes in breast epithelial and breast cancer cells, thereby promoting cellular resistance to ferroptosis [64]
Glutathione, often acclaimed as the 'master antioxidant', is a naturally occurring substance in the body, composed of three amino acids: cysteine, glutamine, and glycine
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