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Conversely, some companies package compounded drugs such that patients must use a syringe to withdraw the medication from a vial

Best Pract Res Clin Endocrinol Metab 23:443452

The short 48-minute half-life necessitates dosing before each major meal (meals containing at least 250 kcal or 30g carbohydrate), typically resulting in 2-3 injections daily

As a result, some people conclude that Melanotan 2 created the issue, when in reality it may have simply increased the contrast between existing areas of pigmentation