Its development program was halted after Phase 2b trials, and it never reached approval as an obesity medication
15,392 In Wistar rats, a diet high in fat was found to lead to a decrease in the ratio of OPG/RANKL, which resulted in increased bone resorption and ultimately a reduction in bone mass
It is also worth noting that clinical trial populations are carefully selected and monitored participants with significant pre-existing gastrointestinal disease are typically excluded and real-world rates of nausea may differ once a medicine reaches broader clinical use
Key Takeaway: Traditional oral supplements are often broken down by stomach acid, leading to slow results
Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial Lau DCW, Erichsen L, Francisco-Ziller N, et al