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Independent of dietary phenylalanine levels or alcohol consumption, the known obligatory gut microbiota-dependent metabolite, PAGln, leads to substantial alterations in central cardiac hemodynamics and vascular dysfunction

Elevated TMAO levels are linked to atherosclerosis, oxidative stress, and an increased risk of cardiovascular disease, diabetes, and chronic kidney disease

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Kidney Issues Some patients may develop kidney problems, including acute kidney injury, particularly if they experience significant dehydration due to side effects like nausea, vomiting, or diarrhoea

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