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Immunofluorescence staining and western blot results verified that GPX1 expression was absent in the cochlear SGNs of gpx1 / mice (Supplementary Figures 1A,C), and there was no significant difference in SGNs number between the gpx1 / mice and WT mice (Supplementary Figure 1B), which indicated that the absence of GPX1 in normal SGNs would not affect the survival of SGNs

This approach allows the body to adjust to the medication's effects on the digestive system while maintaining its therapeutic benefits

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