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Unlike the more receptor-selective MT-1 (Afamelanotide), Melanotan II engages the full breadth of this system, binding MC1R, MC3R, MC4R, and MC5R, making it the compound of choice for researchers who need to study the integrated behaviour of the melanocortin network rather than a single receptor subtype in isolation
doi: 10.1007/s13300-022-01265-5, 6
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