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conducted the present pilot study [2] to examine the ratio of acylcarnitines to free carnitines (AC/FC), a biomarker of cardiomyocyte carnitine insufficiency and impaired -oxidation [3], either in symptomatic HF with reduced left ventricular ejection fraction (LVEF) HFrEF or HF with preserved LVEF (HFpEF), and demonstrated that AC/FC levels in admission were significantly higher than in asymptomatic staged HF, decreasing to comparable levels at discharge
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4 Physiotherapy Programme, School of Rehabilitation Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems
The study included both in vivo analysis from two phase 2 clinical trials and in vitro experiments using primary human hepatocytes
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