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Those with a long half-life (weekly exenatide, efpeglenatide, liraglutide, semaglutide, albiglutide and dulaglutide) produce a sustained activation of rGLP1, resulting in a greater reduction in HbA1c, basal glycemia and body weight and would have fewer gastrointestinal side effects
The Michigan Neuropathy Screening Instrument (MNSI) emphasizes foot inspection and vibration testing, with reported sensitivity of 80% and specificity of 95% versus NDSs 75% and 82%
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In PNA mice, that display modest metabolic dysregulation and overt gonadal perturbations, all multi-agonists decreased body weight (Fig
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