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Considering short half-life of native GLP-2 in human circulation and promising results of teduglutide, which half-life is modestly extended to 35 h, current research focuses on an increase of the time of GLP-2 action by developing new, more stable, GLP-2 analogs
Conclusion: Promising signals are not sufficient for treatment claims
Comparing bioavailability with vs
3) Potential off-target effects: At high doses, they may disrupt normal lipid metabolism or mitochondrial function
doi: 10.1515/revneuro-2015-0021 60 HlscherC
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