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The 12 mg dose was also associated with reductions in several cardiovascular risk factors , including triglycerides, non-HDL cholesterol, systolic blood pressure and high-sensitivity C-reactive protein

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Semaglutide activates only the GLP-1 receptor, while tirzepatide activates both GLP-1 and GIP receptorsa dual-agonist approach that has shown numerically larger weight reductions in clinical trials

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