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[148] The gradual onset of therapeutic effects is characteristic of most antidepressant medications and reflects the complex neurobiological changes that occur with sustained treatment

As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity

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They describe general research findings and do not establish outcomes for compounded preparations or guarantee individual results from this program