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BoNT/X protease cleaves VAMP1 between Arg 68 and Ala 69, and notable de-enrichment at Ala 69 and Asp 70, along with slight de-enrichment at Arg 68 in the substrate profile, suggests that P1, P1 and P2 primarily dictate BoNT/X protease substrate recognition (Fig

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Heres a more detailed look at why its important: Detoxification: Glutathione is crucial for liver detoxification