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Cell (1997) 89(5):74754.10.1016/S0092-8674(00)80257-3 34 YoshimuraNMurakiSOkaHKawaguchiHNakamuraKAkuneT
Mounjaro Mounjaro tirzepatide Eli Lilly GLP-1 GIP GLP-1 Mounjaro GLP-1 GIP GLP-1 Glucagon-like peptide-1-1 GIP Glucose-dependent Insulinotropic Polypeptide- 028800-028805 BMI 30 BMI 27 MTC NEJM SURMOUNT-1 8 12 5% 72 1 15 mg/ 20.9% GLP-1 semaglutide 14% SURPASS 10 mg 40 8.8 HbA1c 23 6 812 5% 40 8.8 NEJM, 2021 72 20.9%NEJM, 2022 // 10 3 5 2.5 mg5 mg7.5 mg10 mg12.5 mg15 mg 4 2.5 mg 4 5 mg 5 7.5 10 12.5 15 mg 1 2/3 GLP-1 15mg 5mg 46 FDA Tirzepatide 28C 21 0C QA 36 47 2448
Culic O, Gruwel M, Schrader J
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Although there have been no head-to-head trials yet, tirzepatide could potentially lead to more significant weight loss with a comparable safety profile to semaglutide, according to an article in Frontiners in Endocrinology
