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Supplied individually at 5mg, they offer researchers the flexibility to run independent concentration-controlled experiments for each compound, side-by-side monotherapy comparison studies, and custom-ratio combination assays enabling a far broader range of experimental designs than a pre-blended stack format allows

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The complexity of neurosteroid-mediated effects, for instance gating of GABA A R (109, 135139) and subunit-specific modulation of glycine and NMDARs (140), suggest the likelihood of multiple binding sites that contribute to potentiating and inhibitory effects ( A Rs also appears to involve modulation of subunit-containing receptors which play a role in tonic inhibition (141145)