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Analysts see US focused alcohol companies facing the most exposure from increased obesity medicine usage and expect a roughly 2% drop in consumption by 2035. As for GLP-1 drug users, survey data from the Brightfield Group suggests that a substantial portion are city dwellers with higher incomes that are actively engaged in exercise and diet management, while a recent survey of 2,000 US consumers from direct-to-consumer company Daily Harvest found that GLP-1 drugs were more appealing to those with self-described very healthy diets

Oral therapies may improve convenience, increase patient adherence, and attract more patients, supporting future market growth

Then there is the M2 macrophage state associated with anti-inflammatory effects, tissue repair and remodeling, promotion of angiogenesis, wound healing, suppression of T-cell responses, secretion of cytokines like IL-10 and transforming growth factor beta (TGF-), and expression of arginase 1 (ARG1), VEGF, and CD206 among others, essentially activity to promote tumor progression (56, 58)

Treatment is well-tolerated

As the drug development landscape evolves, the need for reliable and translational preclinical models has never been greater