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The peptide is structurally derived from native human GLP-1(7-37) with two amino acid substitutions (Aib at position 8 for DPP-IV resistance, Arg substitution at position 34) and a C18 fatty diacid moiety conjugated via a Glu-(AEEA) linker enabling reversible albumin binding and an extended pharmacokinetic profile compatible with once-weekly dosing
More frequent medical oversight than typical clinical care, which some patients value
However, GLP-1 is an endogenous or naturally produced hormone by the gut, while Ozempic is a synthetic mediation containing semaglutide, a man-made version of the human GLP-1 molecule, as its active ingredient
Some patients benefit from staying at 1 mg if they reach their weight loss goals and experience minimal side effects, while others advance to the full 2.4 mg dose for maximum appetite suppression
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