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To help with explanations, a brief summary of the methionine cycle, transsulfuration pathway, and connections to the folate cycle and Betaine (GB) pathway is provided in the next paragraph, and a schematic representation in figure 1

Accordingly (and against accepted convention), the contribution of CYP2E1 to ALD pathophysiology may be more complex than originally thought and is likely dependent on the cellular microenvironment or subject to modulation by other signaling pathways 15,37