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There are sex differences in genomic AR binding within cultured mesenchymal cells from male prostate and female urethra of rats, wherein female tissue presented enrichment of AR at proximal promoter regions and male enrichment was at intergenic regions [112]
For tissue enrichment analysis we downloaded JENSEN tissues database ( calculated mean expression of confidence for each tissue and selected for enrichment analysis the top 30% of high-confidence genes 99
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A 2017 systematic review and meta-analysis identified 12 intervention studies that assessed the effect of L-carnitine or ALCAR on cancer-related fatigue (reported as a primary or secondary outcome) in cancer survivors (108)
Specifically, PT-141 stimulates melanocortin receptors, particularly the melanocortin-4 receptor, located in the hypothalamus
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