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Four potentially lethal toxins have been isolated from the Gila monster's venom, which cause hemorrhage in internal organs and exophthalmos (bulging of the eyes), [38] and helothermine, which causes lethargy, partial paralysis of the limbs, and hypothermia in rats

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Both medications are administered once weekly via injection and have gained attention for their effectiveness

This mechanistic distinction is the focus of ongoing preclinical research

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