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Alterations in mitochondrial functions such as oxidative phosphorylation (OXPHOS) and membrane polarity, which enhance oxidative stress and apoptosis, may precede the development of depressive symptoms [84, 88, 89]

DrBL: So if you find out with a lab test that your red blood cell zinc is low and your iron is low, and then you take zinc and iron and you actually feel worse, youre like, Well, what the heck? Your body actually might be purposefully keeping that iron and zinc low, because your microbiome is a mess

Biochim Biophys Acta (BBA)-Biomembranes (2004) 1664:198205

It is mainly involved in energy metabolism, especially the transport of fatty acids

Insufficient dosing is perhaps the most common issue