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It is worth noting that there exists a synergistic effect in the activation of Toll-like receptors (TLRs) in both the intestine and lungs

Peptidoglycan (PGN) is the main component of the bacterial cell wall, especially for Gram positive bacteria [5], whilst muramidases (EC 3.2.1.17) of the class hydrolases, also known as lysozymes, catalyze the hydrolysis of the PGN at -1, 4 glycosidic linkages level, between N-acetylmuramic acid and N-acetyl-D-glucosamine residues [6, 7]

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