gliptin and glp-1 Insight into Structure Activity Relationship of DPP-4 Inhibitors for Development of Antidiabetic Agents Frontiers | Glucagon-like peptide-1: a

A 2026 study using alanine substitution of phosphorylation sites with single-residue resolution demonstrated that the distal C-tail site primarily governs -arrestin recruitment dwell time, while proximal sites control internalization rate and cAMP duration (Tran et al., 2026)

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