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Careful dose titration is essential, starting with the lowest available dose (2.5 mg weekly) for initiation only, with increases every 4 weeks as tolerated to reach therapeutic doses per FDA labeling

At present, the safe and legal path to access is through a clinical trial

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Second, T2DM patients who received various GLP-1 receptor agonist drugs, such as albiglutide, exenatide, liraglutide, semaglutide, lixisenatide and dulaglutide might have biased the meta-analysis results