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The cycling protocols commonly recommended are partly based on this theoretical concern, though actual tolerance development has not been documented

Because the effective dose reaching the bloodstream is likely lower than with injections, the gastrointestinal side effects that often accompany injectable tirzepatide, particularly constipation , diarrhea , and nausea, tend to be milder with the oral formulation

Immune cell circulating subsets are affected by gonadal function

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FUNDING This research was supported by the Biomedical Research Institute Grant (20220025) of Pusan National University Hospital