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Moreover, increased intracellular levels of GSH are required for the initiation and progression of various types of cancer, and inhibitors of GR behave as anticancer drugs 66 , while high levels of NADPH boost the metastatic ability of melanoma cells, and protocols based on depletion of GSH (isothiocyanates and aziridine derivatives that bind GSH) or based on blocking the uptake of a rate-limiting precursor of its synthesis (inhibitors of the cysteine/glutamate antiporter, XCT) greatly impact cancer cell survival 67,68
Jul 2019;24(5):429-435
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Ethanol consumption induces oxidative stress, leading to an oxidative environment in the endoplasmic reticulum (ER), which results in an imbalance in the unfolded protein response, heightened ERS, and the induction of endogenous cellular apoptosis, ultimately damaging liver cells (Koo et al., 2016)
