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1993;53(18):PL291PL296
Typical duration Long-term, individualized based on response and labs
May your B12 stay adequate, your dose escalation stay smooth, and your results stay worth it.
For context, semaglutide and tirzepatide typically see 4-7% discontinuation rates due to adverse events in their trials
Cortisol normalization could plausibly improve sleep onset, but the effect size and consistency across subjects was modest
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