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Patients with more than one prescription were included ( n = 42,423)

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Copper Content Verification by ICP-MS or ICP-OES Copper analysis applies specifically to the GHK-Cu fraction within the blend, since the 1:1 copper coordination on that component carries the bulk of the molecule's research-relevant activity

Pharmacokinetics and pharmacodynamics In participants receiving apitegromab, trough concentrations of apitegromab steadily increased over time, achieving steady-state levels by week 16 (Extended Data Fig