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Potential causes could include: HIV Conditions like Peutz-Jeghers, neurofibromatosis, McCune-Albright syndrome, Addisons disease, Laugier-Hunziker Some drugs like azathioprines, antimalarials, cytotoxic agents like bleomycin, and contraceptives Diffuse pigmentation not related to melanin could be due to heavy metals, trauma, or a condition known as hemochromatosis
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Some patients find that injecting into areas with more subcutaneous fat, such as the abdomen (at least 2 inches from the navel), produces less burning than leaner areas
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