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found that puerarin could increase the melanin content of melanocytes in vitro , and topical application could improve the melanin content of mouse skin tissue, the mechanism is via activation of the cAMP pathway, followed by elevation of MITF, tyrosinase, Trp-2, and Bcl-2 to increase melanocyte survival and melanin content (Park et al., 2014)
120 NeuefeindT.HuberR.ReinemerP.KnbleinJ.PradeL.MannK.et al (1997b)
TB-500 is a short synthetic peptide corresponding to thymosin 4s actin-binding domain
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