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When adjusted for differences between groups in age, sex, and log(weight), C max was 1020% lower in subjects with RI than in subjects with normal renal function, with no clear trend in severity of RI (Table 2)
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These results directly challenge the assumption that glucagon receptor activation must necessarily impair weight-loss pharmacotherapy
Weight loss rates do slow over time, but this reflects a natural plateau as you approach a lower body weight rather than the medication becoming less effective
Nutrition & metabolism , 7 , 30
